The investigator suggests that local endometrial injury using pipelle catheter performed in the follicular phase (cycle day 5, 6 or 7) of the stimulation cycle may improve the pregnancy rates among patients undergoing intrauterine insemination.
In a selected group of patients with repeated implantation failure, endometrial injury in the preceding cycle may improve ICSI outcome. Little is known about the efficacy of this procedure in improving intrauterine insemination outcome. Also little is known about the effect of this procedure if done in the stimulation cycle weather in ICSI or intrauterine insemination cycles.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
360
Endometrial injury using a pipelle biopsy catheter on day (5, 6 or 7) of the stimulation cycle combined with the intrauterine insemination.
Placement of washed sperm in the uterus using a catheter, around the time of ovulation.
Inducing ovulation by human menopausal gonadotrophin ampoules given intramuscular starting from cycle day two, till the leading follicle reaches 16 - 18 mm.
Chemical Pregnancy Rate
Human chorionic gonadotrophin (b-hcg) detection in serum two weeks after intrauterine insemination.
Time frame: two weeks after intrauterine insemination
Clinical Pregnancy Rate
Ultrasound detection of an intrauterine positive fetal heart pulsations
Time frame: six weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.