Incidence of hypotension is high in parturients after spinal anesthesia. Ephedrine could be used to treat hypotension but lead to lower fetal pH as well. This study is to compare the effects of norepinephrine and ephedrine on hypotension in parturients.
Spinal anesthesia is an accepted technique in elective cesarean sections. However, hypotension, resulted from sympathectomy is a common problem, especially in pregnant women. Prevention of this complication by sympathomimetic agents is of potential clinical significance. Ephedrine could be used to treat hypotension but lead to lower fetal pH, which may be related to worse fetal outcome.Norepinephrine could improve the hypotension to the same extent as phenylephrine. In this study, we tend to compare the effects of norepinephrine and ephedrine on hypotension in parturients and on fetal acid status.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
66
norepinephrine injection
Ephedrine injection
Xijing Hospital,Fourth Military Medical University
Xi'an, Shaanxi, China
incidence of hypotension
Time frame: from immediately after spinal anesthesia to 30min after spinal anesthesia
pH value of fetal arterial blood
Time frame: just after clamp of the umbilical cord, usually 1min to 10min after start of the surgery
incidence of nausea and vomiting
Time frame: from immediately after spinal anesthesia to 30min after spinal anesthesia
incidence of dizzy
Time frame: from immediately after spinal anesthesia to 30min after spinal anesthesia
incidence of chest congestion
Time frame: from immediately after spinal anesthesia to 30min after spinal anesthesia
fetal arterial partial pressure of oxygen
Time frame: just after clamp of the umbilical cord, usually 1min to 10min after start of the surgery
arterial base excess of fetal arterial blood
Time frame: just after clamp of the umbilical cord, usually 1min to 10min after start of the surgery
lowest neonatal cerebral oxygen saturation
Time frame: from clamp of the umbilical cord to 10 min later, 10min in total
lactate level of fetal arterial blood
Time frame: just after clamp of the umbilical cord, usually 1min to 10min after start of the surgery
number of rescue vasoactive agent
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Time frame: from immediately after spinal anesthesia to 30min after spinal anesthesia
incidence of bradycardia
Time frame: from immediately after spinal anesthesia to 30min after spinal anesthesia
incidence of dyspnea
Time frame: from immediately after spinal anesthesia to 30min after spinal anesthesia
Apgar scores of the neonates
The Apgar score is a method to quickly summarize the health of newborn children.It is determined by evaluating the newborn baby on five simple criteria(Appearance, Pulse, Grimace, Activity, Respiration) on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. Scores 7 and above are generally normal; 4 to 6, fairly low; and 3 and below are generally regarded as critically low and cause for immediate resuscitative efforts
Time frame: from clamp of umbilical cord to 1min after clamping
Apgar scores of the neonates
The Apgar score is a method to quickly summarize the health of newborn children.It is determined by evaluating the newborn baby on five simple criteria(Appearance, Pulse, Grimace, Activity, Respiration) on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. Scores 7 and above are generally normal; 4 to 6, fairly low; and 3 and below are generally regarded as critically low and cause for immediate resuscitative efforts
Time frame: from clamp of umbilical cord to 5min after clamping