The primary purpose of this study is to investigate the effects of lidocaine on the total administered dose of fentanyl during sedation for endoscopic mucosal resection. The secondary purpose of this study is to investigate the effects of lidocaine on pain score related with endoscopic mucosal resection at time of 30 min, 6 hr, and 24 hr after procedure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
66
Intravenous administration as bolus of lidocaine 1.5 mg/kg before sedation and infusion of lidocaine 2 mg/kg/hr during sedation. Sedation with fentanyl and propofol
Intravenous administration as bolus of normal saline 0.15 mL/kg before sedation and infusion of normal saline 0.2 mL/kg/hr during sedation. Sedation with fentanyl and propofol
Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine
Seoul, South Korea
Fentanyl consumption during sedation
Time frame: During sedation, an expected average of 40 minutes
Pain intensity measured by numerical rating scale
0 = no pain at all and 10 = worst pain imaginable (11-point numerical rating scale)
Time frame: 30 min, 6 hr, and 24 hr after procedure
Incidence of nausea and vomiting
Nausea requiring antiemetics and retching and/or vomiting
Time frame: Up to 24 hours
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