Usefulness of Chromoendoscopy for the Early Detection of Colorectal Cancer Associated With Inflammatory Bowel Disease

Hospital Clinic of Barcelona350 enrolled

Overview

To assess the feasibility and effectiveness of a program in L-IBD patients using CE targeted biopsies

We aim to know the prevalence and incidence of dysplasia and colitis-associated colorectal cancer in patients with longstanding colonic inflammatory bowel disease (N-IBD), in Spain and the usefulness of advanced endoscopy (chromoendoscopy) for the diagnosis and endoscopic differential diagnosis of N-IBD.

Study Type

OBSERVATIONAL

Enrollment

350

Conditions

Inflammatory Bowel Disease Colorectal Cancer

Interventions

ChromoendoscopyPROCEDURE

Chromoendoscopy involves the topical application of stains to improve tissue localization and characterization of lessions during endoscopy . Chromoendoscopy has been used in patients undergoing colonoscopy, including those undergoing surveillance for chronic ulcerative colitis. Using pit pattern classifications, chromoendoscopy has a high sensitivity and specificity for differentiating neoplastic from non-neoplastic lesions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of UC or colitis EC corroborated by clinical and histology * involvement of at least one third of the colon in patients with CD * involvement proximal to the rectum in patients with UC * Duration of disease \> 10 years * No clinical activity: * May Score \<6 * CDEIS \<3.5 Exclusion Criteria: * Personal history of CRC * colectomy * coagulopathy * refusal to participate in the study * known allergy to indigo carmine * colonoscopy in the last 6 months

Locations (15)

Gastroenteroly Department, Hospital Clinic

Barcelona, Barcelona, Spain

Hospital de Sant Pau

Barcelona, Barcelona, Spain

Hospital del Mar

Barcelona, Barcelona, Spain

Outcomes

Primary Outcomes

Prevalence and incidence of dysplasia and colitis-associated colorectal cancer in patients with longstanding colonic inflammatory bowel disease (N-IBD), in Spain

see title

Time frame: two year

Secondary Outcomes

Usefulness of advanced endoscopy in displasia characterization (chromoendoscopy ) for the diagnosis and endoscopic differential diagnosis of NIBD.

see title

Time frame: two year

Data from ClinicalTrials.gov

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