It has been hypothesized that the biomechanical properties of the optic nerve head and/or sclera play a role in the development of glaucoma. One approach of gaining insight into the biomechanical properties of the eye by the means of clinical studies is based on the Friedenwald equation, representing a pressure-volume relationship. This equation represents the so called ocular rigidity, which expresses the elasticity of the globe. In order to be able to solve the equation, measurements of fundus pulsation amplitude (FPA) with laser interferometry and dynamic contour tonometric assessment of the pulse amplitude (PA) have to be performed. In addition choroidal thickness will be assessed with OCT before and after trabeculectomy, since results in choroidal thickness measurements in patients with glaucoma are controversial. The focus of this study lies on the changes of ocular rigidity and choroidal thickness after surgical trabeculectomy in patients with primary open angle glaucoma (POAG) or pseudoexfoliation glaucoma (PEX).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
53
measured before the operation and 28±7 days after the operation
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Austria
Change in ocular rigidity
Change in ocular rigidity after surgery
Time frame: Baseline and 28±7 days postoperative
Fundus pulsation amplitude
Time frame: Baseline and 28±7 days postoperative
Ocular pulse amplitude
Time frame: Baseline and 28±7 days postoperative
Mean arterial pressure
Time frame: Baseline and 28±7 days postoperative
Pulse rate
Time frame: Baseline and 28±7 days postoperative
Axial eye length
Time frame: Baseline and 28±7 days postoperative
choroidal thickness
Time frame: Baseline and 28±7 days postoperative
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