Er:YAG Laser for Treatment of Enlarged Pores

Mahidol University24 enrolled

Overview

To investigate the efficacy of Erbium:Yttrium aluminum garnet laser (Er:YAG) in the treatment of enlarged pores.

* Enlarged pores are caused by multifactorial factors such as sex, genetics, aging, etc. * The gold of the treatment is to recollagenesis of the dermis and resurfacing of the epidermis. * Modalities that have been proved on their efficacy for enlarged pores treatment included topical retinoic acid, chemical peeling, intense pulsed light, radiofrequency device, laser such as Q-switched and Long Pulsed Neodymium-Doped Yttrium-Aluminum-Garnet (Nd:YAG) 1,064nm, Long pulse duration pulsed dye laser 595nm, etc. * Er:YAG laser is an ablative laser which creates both recollagenesis and resurfacing. It ha been proved to be safe and effective in the treatment of atrophic acne scar. * However, the efficacy of this laser for enlarged treatment has not yet been established.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Enlarged Pores

Interventions

Er:YAG laserDEVICE

Er:YAG laser treats enlarged pores on both sides of the face for 4 treatments of 1 month interval.

Eligibility

Sex: ALLMin age: 25 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Visible enlarged pores on both sides of the face * Fitzpatrick skin type 3-5 Exclusion Criteria: * Patients with lesions with any clinical suspicion of being pre-cancerous or skin malignancies of any kind * Patients who have photosensitive dermatoses * Pregnancy and lactation woman * Patients with wound infections (herpes, other) on the day of treatment * Patients with moderate and severe inflammatory acne, Immunosuppressed patients, history of vitiligo * Patients with unrealistic concerns/expectations and inability to do the appropriate post-operative care

Locations (1)

Department of Dermatology, Siriraj Hospital, Mahidol University

Bangkok, Bangkok, Thailand

Outcomes

Primary Outcomes

The efficacy of Er:YAG laser in the treatment of enlarged pores (measurement of skin texture using UVA-light video camera)

measurement of skin texture using UVA-light video camera

Time frame: 1 month after 4 treatments

Secondary Outcomes

Hyperpigmentation side effect of Er:YAG laser in the treatment of enlarged pores

By investigators' observation of hyperpigmentation

Time frame: Follow-up period:1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment and 1-,3-,and 6-month after 4th treatment

Hypopigmentation side effect of Er:YAG laser in the treatment of enlarged pores

By investigators' observation of hypopigmentation

Time frame: Follow-up period:1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment and 1-,3-,and 6-month after 4th treatment

Erythema side effect of Er:YAG laser in the treatment of enlarged pores

By investigators' observation of erythema

Time frame: Follow-up period:1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment and 1-,3-,and 6-month after 4th treatment

The patients satisfaction using Quartile grading scale of improvement

By using Quartile grading scale of improvement; 0 = not improve, 1= 1-25% improvement, 2 = 26-50% improvement, 3 = 51-75% improvement and 4 = 76-100% improvement

Time frame: Follow-up period:1 month after 1st treatment, 1 month after 2nd treatment, 1 month after 3rd treatment and 1-,3-,and 6-month after 4th treatment

Data from ClinicalTrials.gov

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