A Drug-drug Interaction Study of ALKS 5461 in Healthy Volunteers

Inclusion Criteria: * Has a body mass index (BMI) of 18.0 - 30.0 kg/m\^2 * Is in good physical health * Agrees to use an approved method of contraception for the duration of the study * Additional criteria may apply Exclusion Criteria: * Is currently pregnant or breastfeeding * Has a lifetime history of substance abuse disorder * Has used nicotine within 90 days prior to the study or anticipates a need to use nicotine during the study period * Has used any prescription or over-the-counter medication, including natural health products or dietary supplements (with the exception or prescription contraceptives or hormonal replacements, acetaminophen, ibuprofen, or multivitamins) within 14 days prior to study start * Has used opioids within 30 days prior to screening, or has an anticipated need for opioid medication at any point during the study * Has used alcohol within 72 hours prior to any inpatient period * Is a heavy caffeine drinker (regularly consuming 5 or more caffeinated beverages per day) * Has a history of intolerance or hypersensitivity to opioids (buprenorphine) or opioid antagonists (naltrexone, naloxone) * Additional criteria may apply