This research is based on spleen trapped by dampness and turbid which is the pathogenesis of gouty arthritis.It uses effective prescription of Endocrinology of Dongzhimen Hospital.In this study, the investigators use multi-center randomized parallel controlled clinical trials.The treatment groups are afforded oral traditional Chinese medicine decoction-tonifying spleen and descending the turbid decoction as well as soaking and wet wrapping.The control groups are afforded diclofenac sodium enteric-coated tablets as a positive control drug.The outcome is evaluated by condition of symptoms remission,pain relief time, recurrence rate and laboratory index to determine the efficacy of internal and external treatment.And the research will provide optimized diagnosis and treatment program. The investigators hope this research will also get tonifying spleen and descending the turbid internal and external treatment for gouty arthritis effective clinical treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
120
Ingredient:cortex phellodendrine, rhizoma atractylodis, radix cyathula, coix seed, cotton Bi Xie,rhizoma smilacis glabrae
Ingredient: turmeric, rhubarb, cortex phellodendrine, rhizoma atractylodis, rhizoma arisaema, angelica dahurica,garden balsam stem, pseudobulbus cremastrae seu pleiones
Ingredient:turmeric, rhubarb, cortex phellodendrine, rhizoma atractylodis, rhizoma arisaema, angelica dahurica, pseudobulbus cremastrae seu pleiones.
No.3 Hospital Affiliated to Beijing University of Chinese Medicine
Beijing, Beijing Municipality, China
RECRUITINGDongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Beijing, Beijing Municipality, China
RECRUITINGThe relief of symptoms
This measure is a composite outcome according to the joint red and swollen, joint pain, and restricted movement(Excellent:Complete resolution of symptoms, joint function returning to normal. The score of joint pain, joint red and swollen and joint motion is 0.Effective:The main symptoms mostly disappear. Joint function is improvement, but still have the joint red,swollen,pain and limited activity.Invalid: There is no improvement compared with before treatment).The unit of measure is scale.
Time frame: After take the drug 10 days
The gout relief index
The gout relief index = \[gout relief time (days) ÷ 10 (days)\] x 100%.The unit of measure is scale.
Time frame: After take the drug 10 days
Compare scores of syndrome before treatment and after it.
Using nimodipine method: nimodipine = \[(scores of syndrome before treatment minus score after it) ÷scores of syndrome before treatment\] x 100%.The unit of measure is scale.
Time frame: After take the drug 10 days
Recurrence rate
Recurrence rate=number of patient recurring acute gouty arthritis ÷total cases of each group.The unit of measure is number.
Time frame: Following up for 1 month
Recurrence time
Compare the days of cases recurring acute gouty arthritis of each group.The unit of measure is days.
Time frame: Following up for 1 month
The dosage of colchicine of two groups in observation period
The unit of measure is mg.
Time frame: After take the drug 10 days
Blood uric acid before and after the treatment.
Time frame: After take the drug 10 days
White blood cell count before and after the treatment.
Time frame: After take the drug 10 days
Erythrocyte sedimentation rate before and after the treatment.
Time frame: After take the drug 10 days
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