Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions

University of Colorado, Denver31 enrolled

Overview

This study is designed to learn more about children who have blockage of the left side of their heart. The goal is to determine how much the heart muscle has thickened before surgery and how it changes in the months after surgery. Investigators are also looking for blood tests that may help them predict which patients will have the most thickening pre-operatively and the best return towards normal after surgery. The findings of this study will help the investigators develop new tests to monitor affected patients and develop new therapies to help minimize heart thickening.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Coarctation of Aorta Aortic Stenosis Cardiac Hypertrophy

Interventions

EchocardiogramPROCEDURE

Eligibility

Sex: ALLMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Congenital heart disease patients with the following diagnoses undergoing surgical repair: Coarctation of the aorta (CoA), aortic stenosis (AS), subaortic membrane (sub-AS), supravalvar aortic stenosis (supra-AS). * All patients will have age from birth through 18 years of age. * While we will generally not enroll patients with other co-morbid heart disease that would alter the cardiac physiology (see exclusion criteria), patients with patent foramen ovale, atrial septal defect, and patent ductus arteriosus specifically will be allowed. Exclusion Criteria: * Patients with lesions not listed in inclusion criteria (including but not limited to hypoplastic left heart syndrome, Shone's complex, mitral valve stenosis or regurgitation greater than trivial, non-restrictive ventricular septal defect, interrupted aortic arch, atrio-ventricular canal defect) * Corrected gestational age at time of surgery \<34 weeks * Weight at time of surgery \<2000g. * Patients who will not be seen for any follow-up care at Children's Hospital Colorado

Outcomes

Primary Outcomes

Left ventricular mass

Left ventricular mass will be measured by 2D echocardiography at 1 year after surgical correction.

Time frame: 1 year after surgery

Change in left ventricular mass

Left ventricular mass will be measured by 2D echocardiography prior to surgery, immediately after surgery, and will be compared to that measured at 1 year after surgical correction.

Time frame: Within 1 week prior to surgery, 24-72 hrs after surgery, 1 year after surgery

Secondary Outcomes

Relative wall thickness

A more detailed measure of relative wall thickness (RWT) will be assessed by echocardiography at 1 year after surgical correction.

Time frame: 1 year after surgery

Left ventricular mass

Left ventricular mass will be measured by 3D echocardiography at 1 year after surgical correction.

Time frame: 1 year after surgery

Change in relative wall thickness

Relative wall thickness will be measured by 2D echocardiography prior to surgery and at 1 year after surgical correction.

Time frame: Within 1 week prior to surgery and 1 year after surgery

Change in relative wall thickness

Relative wall thickness will be measured by 2D echocardiography 24-72 hours and at 1 year after surgical correction.

Time frame: 24-72 hours and 1 year after surgery

Change in left ventricular mass

Change in left ventricular mass will be measured by 3D echocardiography 24-72 hours and 1 year after surgical correction.

Time frame: 24-72 hours and 1 year after surgery

Change in left ventricular mass

Change in left ventricular mass will be measured by 3D echocardiography prior to surgery and at 1 year after surgical correction.

Time frame: Within 1 week prior to surgery and 1 year after surgery

Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes