Primary Objective: The purpose of this study is to measure the amount of convection achieved with two different haemodiafilters designed for haemodiafiltration and clotting during haemodiafiltration treatment.
This is a prospective observational cohort pilot study of patients under the care of the Royal Free Hospital with chronic kidney disease who have been established on regular thrice weekly haemodiafiltration treatments in a dialysis centre. Information on the study will be disseminated to the Royal Free consultant nephrologists at the dialysis centre with primary responsibility for the individual patient.
Study Type
OBSERVATIONAL
Enrollment
10
comparison of dialyzers
comparison of dialyzers
convective volume exchanged
volume of convective exchange achieved during the HDF session
Time frame: day 1
platelet and coagulation pathway activation
measurement of coagulation pathway proteins and platelet activation markers
Time frame: day 1
visual coagulation
visual analogue score assessment of clotting in the extracorporeal circuit
Time frame: day 1
small and middle sized solute clearances
dialyzer clearance of small and middle sized molecules, including urea and beta 2 microglobulin
Time frame: day 1
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