a4b7 Integrin in Eosinophilic Esophagitis

Inclusion Criteria: 1. Able to give written informed consent 2. Male or female patients aged 18-65 years at time of screening 3. Confirmed active EoE at screening or within 8 weeks prior to baseline visit, as defined by esophageal mucosal eosinophils ≥15 per high power field (HPF, 400X magnification) despite at least 4 weeks of proton pump inhibitor (PPI) therapy with omeprazole 20 mg twice daily or the equivalent. updated 14APR2015 Page 8 of 19 4. Within the week prior to dosing, patient has one of the following symptoms of moderate, or worse, severity: dysphagia, vomiting, regurgitation, abdominal pain, chest pain/heartburn. 5. Maintained on a stabilized diet for at least 6 weeks prior to screening and during the course of the study; stable diet is defined as no initiation of single or multiple elimination diets or reintroduction of previously eliminated food groups. 6. Willing and able to comply with all clinic visits and study-related procedures 7. Able to understand and complete study-related questionnaires Exclusion Criteria: 1. Another disorder that causes esophageal eosinophilia (e.g., hypereosinophilic syndrome, Churg-Strauss, parasitic infection) 2. History of abnormal gastric or duodenal biopsy or documented GI disorders other than EoE (e.g., celiac disease, Crohn's disease or H. pylori infection) 3. History of the following GI surgeries: fundoplication, gastric surgery or surgery for esophageal atresia 4. Use of systemic immunosuppressive or immunomodulating agents (oral prednisone, anti-immunoglobulin E (IgE) monoclonal antibody (mAb), methotrexate, cyclosporine, INFα, or anti-TNF) within six months prior to study entry. 5. A stricture on endoscopy that prevents passage of the endoscope 6. Participation in any investigational drug or device study within 30 days prior to study entry. 7. Female subjects who are pregnant or nursing. 8. Chronic infections such as HIV, hepatitis B or C, active mycobacterial (TB) or fungal infections. 9. Neoplasm or a history of malignancy in the preceding 5 years. 10. Concurrent infection or disease that may preclude assessment of eosinophilic esophagitis.