PeriOperative ISchemic Evaluation-3 Trial: A Pilot Study

Inclusion Criteria: 1. undergoing noncardiac surgery 2. \>45 years of age 3. expected to require at least an overnight hospital admission after surgery; AND 4. have a preoperative NT-pro-BNP measurement \>100 ng/mL; OR 5. if a preoperative NT-pro-BNP measurement is not available, then the patient must fulfill 1 or more of the following 5 criteria: * history of coronary artery disease * history of peripheral vascular disease * history of stroke * undergoing major vascular surgery * have any 3 of the following 9 risk criteria: * undergoing major surgery * history of congestive heart failure * history of a transient ischemic attack * diabetic and currently taking an oral hypoglycemic agent or insulin * age \>70 years * hypertension * serum creatinine \> 175 umol/L (\>2.0 mg/dl) * history of smoking within 2 years of surgery * undergoing emergent/urgent surgery Exclusion Criteria: 1. planned use of systemic Tranexamic Acid during surgery 2. hypersensitivity or known allergy to TXA 3. creatinine clearance \<30 mL/min (MDRD) 4. history of seizure disorder 5. history of venous thromboembolism 6. acute arterial thrombosis 7. no preoperative measurement of hemoglobin 8. subarachnoid hemorrhage within the past 30 days 9. hematuria caused by diseases of the renal parenchyma 10. previously enrolled in POISE-3 pilot trial 11. not consenting to participate in POISE-3 pilot trial prior to surgery Patients meeting any of the following criteria will be excluded from the Rosuvastatin/Placebo arm: 1. preoperative treatment with a statin or a non statin lipid lowering drug or ciclosporin during the 48 hours before surgery 2. hypersensitivity or known allergy to Rosuvastatin 3. pre-disposed factors for myopathy or rhabdomyolysis