Assessment of the Tolerability of Dry Airflow in the Nasal Cavity During Sleep

Johns Hopkins University

Overview

Preliminary data show that high flow nasal air has been shown to reduce promote heat exchange due to evaporation of nasal mucus by the air flow resulting in heat loss. It is unclear whether unidirectional nasal airflow is well tolerated in healthy individuals. The central hypothesis of this proposal is that dry high flow nasal air will be sufficiently tolerated in healthy adults.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Conditions

Healthy Adults

Interventions

Nasal High FlowDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy men and women * Able to consent * Age ≥ 18 * BMI\<30kg/m2 Exclusion Criteria: * Previous diagnosis of obstructive sleep apnea or sleep disorder * History of Constant Positive Airway Pressure treatment for Obstructive Sleep Apnea * History of recurrent epistasis * Pregnancy (self-report) * Deviated nasal septum * Unstable cardiovascular disease (decompensated Congestive Heart Failure, myocardial infarction or revascularization procedures, unstable arrhythmias) * Uncontrolled hypertension with BP \> 190/110 * Daytime hypoxemia with oxygen saturation\<90% (measured at history and physical examination) * Supplemental oxygen use * Work in transportation industry as a driver or pilot.

Locations (1)

Johns Hopkins University

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

Subjective Tolerability using Questionnaire

Participant response to nasal high flow using 7 point Likert scale

Time frame: Baseline

Data from ClinicalTrials.gov

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