A four-site intradermal rabies booster vaccination in HIV - infected patients who have ever received primary rabies vaccination could improve their immune response to this kind of vaccine.
A four-site intradermal rabies booster vaccination has shown higher immune response than conventional intramuscular rabies booster vaccination in healthy persons. So, the investigators hypothesized the same outcome in HIV - infected patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Rabies vaccine is injected according to the protocol then blood would be drawn for rabies neutralizing antibody, OX-40 assay and cytokines assessment on day 0,7,14.
Queen Saovabha Memorial Institute, Thai Red Cross Society
Bangkok, Thailand
RECRUITINGRabies neutralizing antibody titers
Rabies neutralizing antibody titers would be represented and compared by geometric mean titers (GMTs)
Time frame: Change from baseline of geometric mean titres of rabies neutralizing antibody titres at 2 weeks
Specific T cell response
Specific T cell response is measured by OX-40 assay
Time frame: Change from baseline of percentages of rabies-antigen specific CD4+ T cells at 2 weeks
Cytokines assessment
A few cytokines levels are measured by multiplex bead array assay
Time frame: Change from baseline of cytokines levels at 1 week
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