The purpose of this study is to determine whether Non Invasive Ventilation are effective in prevention of reperfusion pulmonary edema after pulmonary artery angioplasty. Our hypothesis is that administration of Non Invasive Ventilation during the procedure and systematically in post procedure period is a protective factor against the development and severity of reperfusion pulmonary edema.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
236
The same amount of blood sample is collected from both arms of study at the same time of the procedure. In each patient, in the per procedure period, a total of 50 milliliters of blood sample is drawn from the pulmonary circulation downstream and upstream of obstructive lesion, the trunk of pulmonary artery, the superior vena cava and the femoral arterial line prior to angioplasty and at the end of procedure; in the post interventional care unit 10 milliliters of blood sample will be draw daily from the superior vena cava catheter line and femoral arterial line.
Centre Chirurgical Marie Lannelongue
Le Plessis-Robinson, France
RECRUITINGLung Injury Score.
Time frame: Daily during hospitalization in the PACU on day 1 to 7.
Assays of plasma inflammatory markers (InterLeukin-6 , IInterLeukin-8, InterLeukin-10).
The concentration will be given in pg/mL
Time frame: 2 years
Extravascular Lung Water (EVLW) measures.
EVLW is measure by thermodilution technique using a Pulse-Induced Contour Cardiac Output system (PICCO). The unit of EVLW is mL/Kg
Time frame: 2 years
Computed tomography (CT) score
Time frame: 2 years
Doppler pulsatility of the portal vein and its pulsatility ratio
Time frame: 2 years
Pulmonary Vascular Index (PVI) measures
PVI is measure by thermodilution technique using a Pulse-Induced Contour Cardiac Output system (PICCO
Time frame: 2 years
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