In this study the investigators aimed at measuring the effect of a two-week high-fat/high-cholesterol (HFHC) normocaloric diet on HDL particles biochemical composition and HDL function compared to a two-week low-fat/low-cholesterol (LFLC) normocaloric diet.
HDL particles can change their composition and function in response to a variety of pathological conditions and environmental stimuli. It has been previously shown that a western diet is able to drastically modify biochemical composition, anti-inflammatory and anti-oxidant properties of HDL in animals. In humans little is known on the role of diet on HDL function and composition.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
14
The low fat/cholesterol diet had 10% calories from fat and 150-200 mg of cholesterol per day.
The high fat/cholesterol diet had 40% calories from fat and 250-300 mg of cholesterol per day
Azienda Ospedaliero-Universitaria Pisana
Pisa, PI, Italy
Dichlorofluorescein fluorescence slope
Time frame: 14 days
hydroxyeicosatetraenoic acid
Time frame: 14 days
hydroxyoctadecadienoic acid
Time frame: 14 days
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.