Nimotuzumab in Combination With Radiochemotherapy for Patients With Stage IIIA/IIIB Non-small Cell Lung Cancer

Inclusion Criteria: 1. Age from 18 to 70 2. both male and female 3. Subjects with pathologically or cytologically documented stage IIIB or IV NSCLC. Disease must be newly diagnosed. 4. Subjects would refer to the radical radiation therapy, but never have the previous chemotherapy or thoracic radiation therapy. 5. V20\<30%, means that the percentage of the volume of lung which received the radiation\<20Gy accounts the whole volume of lung is less than 30%. 6. Presence of at least 1 uni-dimensionally measurable index lesion,with the longest diameter ≥ 20 mm using conventional computer tomography(CT)/magnetic resonance imaging(MRI)scan or ≥ 10 mm using spiral computed tomography scan. 7. without pulmonary atelectasis, malignant pleural effusion malignant hydropericardium. 8. with ECOG performance status 0-2,and Life expectancy of more than 3 months. 9. without other malignancy history, except curative carcinoma in situ of cervix and skin basal cell carcinoma. 10. functions of major organs( haemogram,heart,liver,kidney)are basically normal, White blood count ≥3.5 x 109/L with neutrophils ≥1.5 x 109/L, platelet count≥100 x 109/L, and hemoglobin ≥90g/L. Total bilirubin ≤1.5 times upper limit of normal (ULN) range; alkaline phosphatase(ALP)≤ 2.5 times ULN, Transaminases AST (SGOT) and ALT (SGPT) ≤ 2.5 times ULN, serum creatinine ≤ 1.2 times ULN . pulmonary function, FEV1≥1L, and \>40% normal value. 11. willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures. 12. both female and male patients must use adequate methods of contraception. 13. Signature of the informed consent Exclusion Criteria: 1. Previous radiotherapy, chemotherapy or anticancer biotherapy. Participation other clinical trials within 1 month prior to inclusion in the trial. 2. with the measureable lesion or lesion could be determined. 3. Severe diseases in lung, i.e. emphysema, interstitial pneumonia, bronchial asthma. 4. uncontrolled diabetes-random plasma glucose; RPG\>11.1mmol/L.（RPG\>11.1mmol/L, blood-fasting sugar; BFS; \<7.8mmol/L，the patient also be enrolled）. 5. With other serious internal diseases or uncontrolled infection. 6. refractoriness dysentery or enterospasm, intestinal obstruction. 7. pregnancy, lactation, fertility but using a prohibited contraceptive method. 8. cardiovascular diseases history, congestive heart failure\>GradeII, New York Heart Association (NYHA) criteria). With the unstable angina, de novo angina ( happened within 3 month prior to inclusion in the trial) or have myocardial in recently six months. 9. With drug addition, I.e. ,drug-taking, drug-taking for long time; type B hepatitis and C hepatitis in active stage, or with AIDS. 10. With organ transplantation,or using adrenocortical hormone or immunosuppressive agents for long time. 11. With history of serious allergic or allergy. 12. Not fit for the clinical trial judged by the investigator.