11C-acetate for Treatment Response After Radiotherapy for HCC

Inclusion Criteria: * \> 18 years of age * Subject is willing to participate in the study and has signed the study informed consent * Subject is available and willing to comply with the protocol evaluations * Diagnosed hepatocellular carcinoma confined to a single lobe of the liver if undergoing 90Y radioembolization * Diagnosed hepatocellular carcinoma confined to the liver if undergoing Stereotactic Body Radiation Therapy (SBRT) * Under consideration for 90Y radioembolization or Stereotactic Body Radiation Therapy (SBRT) Exclusion Criteria: * Pregnant or planning to become pregnant within the next 12 months or breast-feeding * GFR \< 45 * Life expectancy \< 6 months * Claustrophobic and cannot tolerate imaging procedures * Weigh \> 350 lb (upper weight limit of scanner beds) * Special vulnerabilities (e.g. fetuses, neonatales, pregnant women, children, prisoners, institutionalized individuals).