Trans Health: Evaluation of Markers of Cardio-metabolic Health and Well-being in Transgender Youth

University of Colorado, Denver58 enrolled

Overview

This study plans to learn more about puberty blockers and cross (testosterone and estradiol). There is not much known about how these medications affect hormone levels, heart health and overall general health in young transgender individuals.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Transgendered Persons

Eligibility

Sex: ALLMin age: 9 YearsMax age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Followed in Endocrinology Clinic or Adolescent Medicine Clinic at Children's Hospital Colorado * Between age 9 and 21 years (inclusive) * Identifies as transgender * Has been on pubertal blockade or cross-sex hormones for at least three months. Exclusion Criteria: * Known diabetes * Presence of significant medical or psychiatric comorbidities * Using hormones not prescribed by a physician

Locations (1)

Children's Hospital Colorado

Aurora, Colorado, United States

Outcomes

Primary Outcomes

Reproductive hormone concentrations in transgender youth on cross-sex hormones and/or puberty blockers and compared to age-, natal sex- and body mass index (BMI)-matched controls.

Time frame: at enrollment

Markers of cardiometabolic risk in transgender youth on cross-sex hormones and/or puberty blockers and compared to age-, natal sex- and BMI-matched controls

Time frame: at enrollment

Body composition as measured by Dual-energy X-ray absorptiometry (DEXA) in transgender youth compared to age- and BMI-matched controls of both sexes.

Time frame: at enrollment

Data on quality of life as measured by the Pediatric Quality of Life Inventory (PedsQL) compared to published norms

Time frame: at enrollment

Data from ClinicalTrials.gov

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