Previous reports demonstrated that dexmedetomidine could reduce the incidence of postoperative nausea and vomiting (PONV). Dexamethason also had been commonly used for ajuvant drugs for preventing and reducing PONV. So investigator want to study about the effect of dexmedetomidine only or combined with dexamethasone for preventing PONV.
Previous reports demonstrated that dexmedetomidine, a alpha 2 selective agonist could reduce the incidence of postoperative nausea and vomiting (PONV). Dexamethason also had been commonly used for ajuvant drugs for preventing and reducing PONV. So investigator want to study about the effect of dexmedetomidine only or combined with dexamethasone for preventing PONV.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
150
administration of dexmedetomidine only
administration of dexmedetomidine and dexamethasone
administration of normal saline
Postoperative Nausea (Numeric Rating Scale for Nausea)
Numeric rating scale for postoperative nausea (scores on a scale) (0-no symptoms; 10-worst symptoms imaginable). Ramosetron 0.3 mg was administered to patients with nausea \>5 points on the numeric rating scale
Time frame: Changes from baseline in postoperative nausea at 30 min
Postoperative Vomiting (Number of Participants With Vomiting)
frequencies of vomiting (number of participants with vomiting) 24 hour post-operatively
Time frame: Changes from baseline in postoperative nausea at 30 min
Rhodes Index Score
Rhodes Index of nausea, vomiting, and retching at 6 to 24 hours after surgery (ask 8 question about discomfort due to PONV and each questions are consist of 0\~4 score) (minimal PONV 0 to maximal PONV 32) lower values represent a bettwer outcome
Time frame: assessed at 6 and 24 hour after operative end
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