This study aims to evaluate prevalence of sarcopenia and cachexia in patients with chronic cardiopulmonary disease. The investigators will also investigate metabolic disorders like glucose metabolism, presence of metabolic syndrome, body composition and histological changes in skeletal muscle and body fat. Finally, patients will be followed for clinical endpoints.
Study Type
OBSERVATIONAL
Enrollment
400
General Hospital Celje
Celje, Slovenia
RECRUITINGInsulin resistance (HOMA-IR)
HOMA-IR as calculated by formula using insulin and blood glucose
Time frame: Baseline
Muscle strength (Handgrip test)
Handgrip test
Time frame: Baseline
Change in exercise capacity (6 minute walk test)
Determined by incremental exercise test, 6 minute walk test
Time frame: baseline and after 5 weeks
Neurohormonal activation (NT-proBNP concentration)
NT-proBNP concentration
Time frame: Baseline
Change in apoptosis in skeletal muscle (number of apoptotic cells per square mm)
histological evaluation: number of apoptotic cells per square mm
Time frame: Baseline and after 5 weeks
Change in insulin resistance (HOMA-IR)
HOMA-IR as calculated by formula using insulin and blood glucose
Time frame: Baseline and after 5 weeks
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