This multicenter, prospective, observational cohort study will assess bone differences in women and men with type 2 diabetes mellitus (T2DM) with and without fragility fractures.
Cross-sectional evaluation of clinical, biochemical and microstructural measures of bone in patients with type 2 diabetes and age-matched healthy controls. Longitudinal assessment of clinical, biochemical and microstructural measures of bone in study participants without prevalent fragility fractures.
Study Type
OBSERVATIONAL
Enrollment
274
Department of Internal Medicine, Kantonsspital Bruderholz
Binningen, Basel-Landschaft, Switzerland
University Department of Internal Medicine, University Basel, Kantonsspital
Aarau, Canton of Aargau, Switzerland
Department of Internal Medicine, Kantonsspital Luzern
Lucerne, Canton of Lucerne, Switzerland
Department of Medicine, St. Anna Hospital Hirslanden
Lucerne, Canton of Lucerne, Switzerland
Intra-cortical pore volume
Intracortical pore volume using HR-QCT femoral shaft and mid-tibia and HR-pQCT at the distal radius (mm3)
Time frame: 2 years
Areal Bone Mineral Density (aBMD)
Areal BMD of the spine, the proximal femur and the distal radius (assessed by DXA)
Time frame: 2 years
bone turnover markers
alcaline phosphatase, crosslinks
Time frame: 2 years
advanced glycation end products (AGE)
urinary pentosidine levels
Time frame: 2 years
Occurence of fractures during follow up
incident fracture history
Time frame: 2 years
Volumetric Bone Mineral Densitiy (vBMD)
vBMD of the proximal femur, including trabecular and cortical bone in the femoral neck and Trochanter (assessed by HR-QCT)
Time frame: 2 years
Cortical thickness and porosity
assessed by HR-QCT at the caudal Region of the femoral neck or the proximal third of the femoral shaft
Time frame: 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Division of Endocrinology, Diabetology and Metabolism, University Hospital Basel
Basel, Switzerland