The purpose of this study is to determine effect of combined medication of sufentanil and dexmedetomidine in patient controlled analgesia after neurosurgery.
Sufentanil is a classical drug for postoperative analgesia. Dexmedetomidine is a commonly used α2-adrenergic receptor, and it helps provide sedation, analgesia and inhibition of sympathetic activation. The investigators propose to recruit 120 patients who is undergoing the arteriovenous malformation embolism operation in department of Neurosurgery. Patients will be randomly divided into 4 groups(control group, sufentanil and low dexmedetomidine dose group, sufentanil and middle dexmedetomidine dose group, sufentanil and high dexmedetomidine dose group), then the investigators select post-operative records to determine whether dexmedetomidine can take a positive role in neurosurgical analgesia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
120
sufentanil 150μg， intravenous administration during post-operative 72 hours.
dexmedetomidine 0.05μg/kg/h, Continuous intravenous injection for 72 hours after operation
dexmedetomidine 0.1μg/kg/h, Continuous intravenous injection for 72 hours after operation
the First Affiliated Hospital of Sun Yetsen University
Guangzhou, Guangdong, China
RECRUITINGPain on the VAS scale
measure the VAS score at pre-operative day and post-operative 4h、8h、12h、24h、48h、72h。
Time frame: within the following 72 hours after surgery
blood pressure(BP)(mmHg)
measure BP(mmHg),HR (/min),spO2(%), and breath(/min),on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
Time frame: within the following 72 hours after surgery
heart rate(HR) (/min)
measure BP(mmHg),HR (/min),spO2(%), and breath(/min),on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
Time frame: within the following 72 hours after surgery
spO2(%)
measure BP(mmHg),HR (/min),spO2(%), and breath(/min),on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
Time frame: within the following 72 hours after surgery
breath(/min)
measure BP(mmHg),HR (/min),spO2(%), and breath(/min),on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
Time frame: within the following 72 hours after surgery
sedation level on ramsay sedation score
measure sedation level using ramsay sedation score on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
Time frame: within the following 72 hours after surgery
vomit times
measure vomit times on pre-operative day and at measure sedation level using ramsay sedation score on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
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dexmedetomidine 0.15μg/kg/h, Continuous intravenous injection for 72 hours after operation recorded in the following 72h.
Time frame: within the following 72 hours after surgery
nausea
measure whether nausea exists on pre-operative day and at measure sedation level using ramsay sedation score on pre-operative day and at post-operative 4h、8h、12h、24h、48h、72h
Time frame: within the following 72 hours after surgery