Investigators plan to explore whether Omega-3 fatty acid have effect on the violent behavior of the schizophrenia patients. Investigators will use PET to explore the influence on serotonin function of the brain to understand the mechanism of how Omega-3 fatty acid works. This study will enroll 100 patients of schizophrenia with violent behavior.Participants will be split into two groups randomly. In one group, participants will receive one pill of placebo per day, and in the other, participants will have one pill of 900mg Omega-3 fatty acid per day. This intervention will last 3 months.At week 0, week 4, week 8 and week 12, some scales will be evaluated. Meanwhile, the density of eicosapentaenoic acid(EPA),docosahexaenoic acid (DHA),noradrenalin(NE), dopamine(DA) and serotonin(5-HT) in blood will be tested.At week 0 and week 12, 10 patients of each group will be randomly selected to have the exam of PET.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
omega-3 fatty acid
placebo
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China
RECRUITINGviolent behavior of Participants as Assessed by Modified Overt Aggression Scale(MOAS)
change in violent behavior of participants
Time frame: up to 24 months
psychiatry symptoms of participants as assessed by Positive and Negative Syndrome Scale (PANSS)
change in psychiatry symptoms of participants
Time frame: up to 24 months
blood level of eicosapentaenoic acid(EPA), docosahexaenoic acid (DHA), noradrenalin(NE), dopamine(DA) and serotonin(5-HT) of participants
change in the blood level of DHA, EPA, 5-HT, DA and NE at baseline, 4 weeks, 8 weeks and 12 weeks
Time frame: up to 24 months
the density of 5-HT1A receptor in brain tested by positron emission tomography (PET)
change of the density of 5-HT1A receptor in different groups
Time frame: up to 24 months
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