Transciptomic Modification Induced by miRNAs in Endometrial Fluid

Stanford University10 enrolled

Overview

The purpose of this study is to understand the mechanism of communication between the uterine environment and the preimplantation human embryo. The investigators are interested in understanding how the in-utero environment during the window of implantation is different in normal weight and overweight/obese women and how this may impact the programming of the developing embryo.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

MicroRNA in Endometrial Fluid

Interventions

Endometrial fluid aspirationPROCEDURE

Patient will undergo a biopsy to aspirate endometrial fluid from the uterine cavity

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Meet the WHO criteria for normal weight (BMI \< 25) and overweight/obese (BMI \> 25) * Age 21-45 Exclusion Criteria: * Age \< 21 or \> 45 * Women with history of hysterectomy

Locations (1)

Stanford University

Stanford, California, United States

Outcomes

Primary Outcomes

Gene expression profile in human embryos

We will perform RNA sequencing on the human embryo to quantify which genes are up and down regulated in obese compared to normal weight controls.

Time frame: Samples will be collected within 1 month of enrollment

Data from ClinicalTrials.gov

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