The Prime Study - Comparing Hepatitis C Care and Treatment in a Primary Health Care Service With a Tertiary Hospital

Inclusion Criteria: * Aged ≥18 years; * Attendance at a study PHCS defined as; Attended appointment at PHCS at least once in 2014 or; Attended at least one consultation with a study community hepatitis nurse between 2012-2014 * Evidence of chronic G1 HCV infection (HCV antibody positive for \> 6 months and HCV RNA positive); * Absence of cirrhosis defined as one of the following: Liver biopsy within 24 months prior to screening demonstrating absence of cirrhosis (e.g. a Metavir score of 3 or less or an Ishak score of 4 or less); or A screening FibroScan result of \<9.6 kPa; or if a FibroScan is unsuccessful A screening Aspartate Aminotransferase to Platelet Ratio Index (APRI) ≤ 2 and no clinical or laboratory evidence of cirrhosis; * HCV treatment naive or pegylated or standard interferon and ribavirin experienced; * Willing and able to provide written informed consent Subjects must have the following laboratory parameters at screening: * ALT ≤ 10 times the upper limit of normal (ULN); * AST ≤ 10 times ULN * Haemoglobin ≥ 12g/dL for males; ≥ 11g/dL for female subjects; * Platelet count ≥ laboratory lower limit of normal; * INR ≤ laboratory upper limit of normal, unless stable on an anticoagulant regimen affecting INR; * Albumin ≥ laboratory lower limit of normal; * Direct bilirubin ≤ laboratory upper limit of normal; * Creatinine clearance (Clcr) ≥ 60mL/min as calculated by Cockcroft-Gault equation. Exclusion Criteria: * Known cirrhosis defined as: Liver biopsy within 24 months prior to screening demonstrating cirrhosis (e.g. a Metavir score \> 3 or an Ishak score \> 4); or A FibroScan result of \>12.5 kPa; or Prior clinical evidence of cirrhosis or portal hypertension (i.e. ascites, varices). * Prior exposure to HCV DAA protease inhibitors * Currently receiving HCV treatment; * Testing positive for HIV; * Testing positive for HBsAg; * HCC; * Pregnancy or breastfeeding at screening or baseline; * Evidence of any condition, therapy, laboratory abnormality or other circumstance (current or prior) that may confound the study's results, or interfere with participation for the full duration of the study, such that it is not in the best interest of the participant; * Use of concomitant medications that are contraindicated with Viekira Pak within 28 days of the baseline/day 1 visit, that are unable to be ceased for the duration of treatment. Additional exclusion criteria for participants receiving ribavirin: * increased baseline risk for anaemia (i.e. history of thalassaemia, spherocytosis, history of GI bleeding) or; * patients for whom anaemia would be medically problematic or; * documented of presumed coronary artery disease or cerebrovascular disease, if in the judgement of the investigator, an acute decrease in haemoglobin by up to 4 g/dL (as may be seen with ribavirin) would not be well tolerated.