This study evaluates the efficacy of cognitive training in subjects with subjective memory impairment. The first group will receive cognitive training and lifestyle modification in combination, the second group will receive only lifestyle modification, and the third group will receive no intervention.
Subjective memory impairment is currently thought to be a risky state of progression to Alzheimer's disease. This study aims to confirm whether cognitive training in subjective memory impairment would show improvement in the subjective and objective cognition. We include subjects with normal cognition but complained subjective feeling of memory decline and conduct cognitive training programs combined with lifestyle modifications for 3 months. We evaluate the neuropsychological tests and questionnaires about subjective improvement after 3 months of interventions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
65
cognitive training is held 2 times a week for 3 months, 90 minutes per 1 session. It includes cognitive exercise of multiple cognitive domains such as memory, attention, calculation, executive function and visuospatial function.
education about lifestyle modification is done by investigators at the first day of the trial and the investigators conduct weekly phone call to participants to educate the lifestyle modifications
Jae-Hong Lee
Seoul, South Korea
Paired associates learning test
paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.
Time frame: 3 month
Rapid visual information processing test
rapid visual information processing is a part of computerized neuropsychological test battery named CANTAB. The score is shown as correct response rate.%
Time frame: 3 month
Pattern recognition memory test
paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The score is shown as correct response rate.%
Time frame: 3 month
Spatial working memory test
paired associates learning test is a part of computerized neuropsychological tests battery named CANTAB (Cambridge Neuropsychological Test Automated Battery). The scores are shown as total number of errors.
Time frame: 3 month
cognitive failure questionnaire
questionnaire for measuring self reported cognitive status. score range: 0-100. Higher score means worse cognitive status.
Time frame: 3 month
Mini-mental state examination
mini-mental state examination that examines general cognition. range 0-20. Higher score means better cognition.
Time frame: 3 month
Geriatric depression scale
questionnaire for depression measuring. score range:0-15. lower score means less depression.
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Time frame: 3 month
Beck anxiety index
questionnaire for self reporting anxiety measuring. range:0-63. low score means less anxiety.
Time frame: 3 month
Seoul instrumental activities of daily living
scale for measuring activities of daily living limitation. score range 0-45. low score means better ability.
Time frame: 3 month
Rey complex figure copy test
test for visuospatial function. Participants should copy the complex figure. score range: 0-36. Higher score means better visuospatial function.
Time frame: 3 month
Digit symbol test
a test for attention and psychomotor speed. Participants are instructed to write an appropriately matched code for each number. Correct number is counted. score range: 0-76. Higher score means better function.
Time frame: 3 month
Seoul verbal learning test, immediate recall
measuring tool for immediate memory function. Investigators read 12 words to participants. Participants should remember the words. Tests are done 3 times. score range: 0-36. Higher score means better immediate memory function
Time frame: 3 month
Seoul verbal learning test, delayed recall
measuring tool for 20 minutes delayed memory function. After 20 minutes from the immediate recall test, participants should remember the words. score range: 0-12. Higher score means better delayed memory function
Time frame: 3 month
Seoul verbal learning test, delayed recall
measuring tool for cued recall of verbal memory function. score range: 0-24. 2. Higher score means better memory recognition function
Time frame: 3 month
Logical memory test, delayed recall
logical memory test is a part of a neuropsychological test named Wechsler
Time frame: 3 month