Global, Multicentre, Non Interventional Advagraf Conversion Registry in Kidney Transplant Patients

Change in renal function as measured by eGFR using the CKD-Epi formula

Chronic Kidney Disease Epidemiology Collaboration (CKD-Epi)

Time frame: At transplantation, within 3 months after transplantation, up to 2 years pre-conversion and then every 6 months prior to conversion, at conversion (baseline), 12 months post-conversion and annually thereafter until EOS (up to 5 years post conversion)

Overall patient survival

Patients who are lost to follow up or alive at EOS - or at time of analysis will be censored

Time frame: From transplantation to EOS (up to 5 years post conversion) or date of death from any cause

Overall graft survival (time to graft loss)

Defined as time from transplantation to graft loss. Graft loss is defined as re-transplantation, nephrectomy, death or as dialysis ongoing at end of study or at the time of discontinuation of the patient from the study. The date of graft loss is the earliest date of any of these events. In case of dialysis as reason for graft loss, the date of graft loss is the first day of the last ongoing dialysis period reported

Time frame: From transplantation to date of graft loss

DSA status (de novo)

Donor Specific Antibody (DSA). Laboratory assessment performed where possible in accordance with standard of care

Time frame: From transplantation to EOS (up to 5 years post conversion)