Adenomyosis is characterized by the appearance of endometrial cells in the muscular layer of the uterus. It affects about 15-20% of the female population. The symptoms of adenomyosis are heavy menstrual bleedings and painful menstruation (dysmenorrhea) and in addition chronic pelvic pain. Regarding treatment levonogestrel-releasing intrauterine system, Gonadotropin releasing hormone (GnRH)-analogues, Danazol, uterine embolization and endometrial ablation have been tried. The aim of this study is to compare the efficacy and usefulness of association of oral contraceptive pill and LNG-IUS or LNG-IUS alone
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
50
LNG-IUS
Levonorgestrel 0,10 mg+ethinylestradiol 0,02 mg oral contraceptive pill in continuous regime
Change of Pelvic pain as measured by visual analogue scale
Time frame: Change from baseline pelvic pain at 45 days of treatment
Change of Pelvic pain as measured by visual analogue scale
Time frame: Change from baseline pelvic pain at 90 days of treatment
Change of Pelvic pain as measured by visual analogue scale
Time frame: Change from baseline pelvic pain at 180 days of treatment
Change of Pelvic pain as measured by visual analogue scale
Time frame: Change from baseline pelvic pain at 365 days of treatment
Quality of sexual life
Time frame: Cases were administered and fulfilled the questionnaires at the moment of diagnosis of adenomyosis up to 4weeks; Change from baseline were evaluated 45 days after begin of treatment
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