In Vivo Endomicroscopic Description of Pulmonary Microcirculation in Systemic Sclerosis and Emphysema Patients

Inclusion Criteria: * Patients with scleroderma with diffuse interstitial pneumonia, indicating a bronchoscopy. * Patients with pulmonary emphysema indication for bronchoscopy. * Age greater than 18 years. * Having an affiliation to social security. * Signed informed consent. Exclusion Criteria: * Severe chronic respiratory insufficiency against-indicating the completion of a bronchoscopy * Hypercapnia defined by a PaCO2 ≥ 6 kPa * Disorders of hemostasis against-indicating performing a bronchoscopy * Anticoagulant therapy can not be interrupted time of completion of the examination * A history of pneumonectomy or contralateral exploration in a nonfunctional lung * Contraindication to the injection of fluorescein (including treatment with beta-blocker eye drops or po) or one of its excipients * History of an injection poorly tolerated fluorescein * A history of food allergy or drug known * Myocardial infarction \<1 month * Unstable angina * Pregnant or lactating woman, premenopausal women without adequate contraception * Person under guardianship * Patient participating in another trial / participating in another trial within 4 weeks