Simultaneous Modulated Accelerated Boost Versus Standard Dose Radiotherapy in Esophageal Cancer

Inclusion Criteria: * Histologic proof of primary squamous cell carcinoma of the esophagus. * Primary disease at cervical, upper or middle thoracic esophagus * T1-4, N any, M0 (except supraclavicular lymph node). * Age≥18 \& ≤75. * ECOG score 0-2. * Platelets ≥ 150,000, Hgb ≥ 10 gm%, ANC ≥ 1500, serum creatinine ≤ 1.5 mg/dl. * Adequate liver function. * Patients with prior malignancy are eligible if disease-free ≥ 5 years. * No prior chest radiotherapy, systemic chemotherapy or major esophageal surgery. * Signed study-specific informed consent form prior to study entry. Exclusion Criteria: * Patients with tracheo-esophageal fistula. * Patients with invasion into mucosa of trachea or major bronchi. * Patients with uncontrolled serious medical or mental illnesses. * Prior RT that would result in overlap of planned RT fields. * Pregnancy or women of childbearing potential and men who are sexually active * Women who are breastfeeding a baby.