Bioavailability of Belumosudil (KD025) in Healthy Male Subjects

Inclusion Criteria: To be eligible for study entry subjects has to satisfy all of the following criteria: 1. Healthy males 2. Aged 18 to 55 years of age 3. Good state of health (mentally and physically) as indicated by a comprehensive clinical assessment (detailed medical history and a complete physical examination), ECG, and laboratory investigations (hematology, coagulation, clinical chemistry and urinalysis) 4. Body mass index 18.0-30.0 kg/m\^2, or if outside the range, considered not clinically significant by the Investigator 5. Willing and able to communicate and participate in the whole study 6. Provide written informed consent 7. Agree to use an adequate method of contraception for up to 90 days post discharge Exclusion Criteria Subjects are excluded from the study if one of more of the following statements is applicable: 1. Participated in a clinical research study within the previous 3 months 2. Study site employees, or immediate family members of a study site or sponsor employee 3. Had been previously enrolled in this study 4. History of any drug or alcohol abuse in the past 2 years 5. Regular alcohol consumption \> 21 units per week (1 unit = ½ pint beer, 25 mL of 40% spirit or a 125 mL glass of wine) 6. Current smokers and those who had smoked within the last 12 months. A breath carbon monoxide (CO) reading of greater than 10 ppm at screening 7. Did not have suitable veins for multiple venepunctures/cannulation as assessed by the Investigator at screening 8. Clinically significant abnormal biochemistry, hematology, coagulation, or urinalysis as judged by the Investigator 9. Positive drugs of abuse test result or alcohol breath test 10. Positive hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody (Ab) or human immunodeficiency virus (HIV) results 11. History of any clinically significant cardiovascular, renal, hepatic, chronic respiratory or gastrointestinal (GI) disease that may have compromised the subject's safety or interfered with the objectives of the study as judged by the investigator 12. Subject had a history or presence of any of the following: * Active GI disease requiring therapy * Hepatic disease and/or alanine aminotransaminase (ALT) or aspartate aminotransaminase (AST) \> 1.5 × upper limit of normal (ULN) at screening * Renal disease and/or serum creatinine \> 1.5 × ULN at screening * Other condition known to interfere with the absorption, distribution, metabolism or excretion of drugs 13. QT interval corrected using Fridericia's formula (QTcF) \> 450 msec at the screening or admission ECG 14. Serious adverse reaction or serious hypersensitivity to any drug or the formulation excipients 15. Known sensitivity to ROCK2 inhibitor agents or to any of the constituents of the belumosudil formulation 16. Presence or history of clinically significant allergy requiring treatment, as judged by the Investigator. Hayfever is permitted unless it is active. 17. Donation or loss of \> 400 mL of blood within the previous 3 months 18. Taking or had taken any prescribed or over-the-counter drug (other than 4 g per day paracetamol) or herbal remedies in the 14 days before IP administration 19. Fails to satisfy the Investigator's discretion of fitness to participate or for any other reason Additional Restrictions 1. Abstain from alcohol during the 24 h prior to each admission until discharge from the clinic in each study period 2. Not to drink liquids or eat food containing grapefruit, cranberry, caffeine, or other xanthines from 24 hours prior to each admission until 48 hours post-dose 3. Refrain from eating food containing any seeds (e.g., poppy) for 48 hours before the screening visit and then from 48 h prior to each admission until discharge from the clinic for each study period 4. Not to take part in any unaccustomed strenuous exercise from 72 hours prior to the screening visit and then from 72 hours prior to admission until discharge from the study