cAMP Signaling and Muscle Adaptations

University of Copenhagen72 enrolled

Overview

The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the present study is thus to investigate the role of cAMP signaling by beta2-adrenergic stimulation for muscle adaptations in humans.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Muscle Hypertrophy in Healthy Young Men

Interventions

No trainingOTHER

Endurance trainingOTHER

Resistance TrainingOTHER

TerbutalineDRUG

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy young men * 18-35 years of age * Informed consent * Active 2-5 hours of training pr. week * Maximal oxygen uptake (ml/min/kg) of 40-60 * Lean body mass of 55-65 kg / Lean mass index 14-22 kg/m2 Exclusion Criteria: * Smoker * Allergy towards study drugs * Chronic disease

Locations (2)

Department of Nutrition, Exercise and Sports

Copenhagen, Denmark

RECRUITING

Bispebjerg University Hospital

Copenhagen, Denmark

RECRUITING

Outcomes

Primary Outcomes

Muscle hypertrophy (lean body mass in Kilograms)

Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)

Time frame: 2 days

Secondary Outcomes

Energy turnover (ml/min or mmol/kg dry weight muscle)

Pulmonary gas exchange and lactate and glycogen will be measured in muscle biopsies obtained before and after intense exercise

Time frame: 1 day

Central Contacts

Morten Hostrup, PhD

CONTACT

+4524474785 mortenhostrup@gmail.com

Data from ClinicalTrials.gov

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