This trial is conducted in Europe. The aim of this trial is to compare the steady-state exposure of semaglutide administered subcutaneously once daily to semaglutide administered subcutaneously once weekly in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
113
Administered subcutaneously (s.c., under the skin)once daily or once weekly.
Administered subcutaneously (s.c., under the skin)once daily or once weekly.
Novo Nordisk Investigational Site
Berlin, Germany
Area under the semaglutide concentration-time curves
Time frame: At steady-state from 0 to168 hours after dosing on day 78
Maximum observed semaglutide plasma concentration
Time frame: At steady-state derived from the concentration-time curves, within 168 hours from day 78
Number of treatment emergent adverse events (TEAEs)
Time frame: From baseline (day 1, post-dose) to last follow-up visit (day 120)
Area under the the single dose concentration-time curve
Time frame: From 0 to 300 min after administration of paracetamol (1.5 g) at day 51
Area under the the single dose concentration-time curve
Time frame: From 0 to 300 min after administration of paracetamol (1.5 g) at day 79
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