This current project investigates the effect of a single session of right dlPFC repetitive transcranial magnetic stimulation on emotion regulation abilities and craving in alcohol dependent patients and healthy controls.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Enrollment
80
Repetitive 10Hz right DLPFC stimulation using Magstim TMS apparatus
Change in BOLD response during an emotion regulation task (fMRI)
BOLD response was measured during an emotion regulation task. The change in BOLD response between sessions is the primary outcome for this study
Time frame: Change in BOLD response from baseline, compared to BOLD response after stimulation (approximately two weeks later)
Change in experienced emotion during an emotion regulation task with Visual Analogue Scales (VAS)
Participants were instructed to either 'attend' or 'regulate' their emotion associated with the presented (negatively valenced) pictures. Experienced (or regulated) emotion was assessed with visual analogue scales (VAS).
Time frame: Change in experienced emotion from baseline, and after the stimulation session (approximately two weeks later)
Change in craving levels [Alcohol Urge Questionnaire (AUQ)]
The AUQ was administered in order to assess craving levels. The AUQ consists of eight statements wich are rated on a 7 point likert scale \[0 = Strongly disagree, 6 = Strongly Agree\]
Time frame: Before and after the emotion regulation task, during both baseline and stimulation session (e.g. 4 time points, sessions were separated by approximately two weeks)
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