MIC Cell Therapy for Individualized Immunosuppression in Living Donor Kidney Transplant Recipients

Inclusion Criteria: * Chronic kidney disease stage KDIGO 4 or 5 * First kidney transplant from a living donor * Age ≥ 18 years * ABO compatible * CDC-PRA \< 20% * No donor-specific antibodies * Negative CDC and ELISA crossmatch * Immunosuppression with cyclosporin A, EC-MPS and methylprednisolone * Informed consent * Adequate contraception (women with child bearing potential) Exclusion Criteria: * Psychiatric disorder * Heart failure (NYHA III or IV) * Severe liver disease * Active hepatitis B or C or HIV infection * Active bacterial, fungal or viral disease * Malignancy or malignancy in the last 5 years before screening * Preexisting immunosuppression * Vaccination with a live vaccine in the last 3 months before screening * S/p splenectomy * Substance abuse * Pregnancy or lactation * Women: Child/pregnancy with the intended donor * Allergy against the investigational drug or part of it * Other diseases that prohibit participation in the study (in the opinion of the investigator) * Participation in an other interventional study