Postoperative Analgesic Effect of Nefopam

Seoul National University Bundang Hospital78 enrolled

Overview

Nefopam will be administered to the patients undergoing laparoscopic gastrectomy under the total intravenous anesthesia (TIVA). The investigators will evaluate whether the nefopam can decrease the total amount of remifentanil administered during the operation, which will reduce the acute opioid tolerance and following consumption of fentanyl during postoperative period.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Stomach Neoplasms

Interventions

NefopamDRUG

SalineDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Early or advanced gastric cancer Exclusion Criteria: * Refusal * Use of preoperative analgesic drugs * Pregnancy * Recurred gastric cancer * Seizure * Cardiac disease * Monoamine oxidase inhibitor * Urologic disease * Previous intrabdominal surgery * Body mass index \> 30 or \< 16

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

Change of the administered fentanyl dose from postoperative 6 h to postoperative 5 day

Time frame: postoperative 6 h, postoperative 1 day, postoperative 2 day, postoperative 3 day, postoperative 5 day

Secondary Outcomes

Change of the pain score from postoperative 6 h to postoperative 5 day

Time frame: postoperative 6 h, postoperative 1 day, postoperative 2 day, postoperative 3 day, postoperative 5 day

Data from ClinicalTrials.gov

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