The excess production of colonic short-chain-fatty-acids (SCFA) has been implicated in the promotion of obesity, but colonic fermentation of dietary-fiber to SCFA may also play a role in preventing diabetes. The investigators aimed to compare the effects of two fermentable fibers (inulin and resistant-starch) on postprandial SCFA, glucose, insulin, free-fatty acids (FFA) and gut hormone responses and to compare the responses in healthy overweight and obese (OWO) vs lean (LN) participants. Methods: Using a randomized, single blind, crossover design, 13 OWO and 12 LN overnight fasted participants were studied on 3 separate occasions. On each day they consumed a 300 mL drink containing 75g glucose (Control) or 75g glucose plus 24g inulin (IN), or 28.2g resistant-starch (RS). A standard lunch was served 4 h after the test drink.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
25
75g glucose
75g glucose plus 24g inulin
75g glucose plus 28.2g resistant starch
Incremental area under the serum acetate response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the serum propionate response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the serum butyrate response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the breath hydrogen response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the breath methane response curve
Time frame: For 6 hours after consuming the test meal
Incremental area under the serum glucose response curve
Time frame: For 4 hours after consuming the test meal
Incremental area under the serum glucose response curve
Time frame: For 2 hours after consuming the standard lunch
Incremental area under the serum insulin response curve
Time frame: For 4 hours after consuming the test meal
Incremental area under the serum insulin response curve
Time frame: For 2 hours after consuming the standard lunch
Incremental area under the serum c-peptide response curve
Time frame: For 4 hours after consuming the test meal
Incremental area under the serum c-peptide response curve
Time frame: For 2 hours after consuming the standard lunch
Total area under the serum free-fatty acid response curve
Time frame: For 4 hours after consuming the test meal
Total area under the serum free-fatty acid response curve
Time frame: For 2 hours after consuming the standard lunch
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