This observational cohort aimed to re-evaluate the outcome of hematologic cancer patients admitted to the intensive care unit of Mansoura oncology center through a cohort study as regards their need for mechanical ventilation during two years.
It has been believed for many years that the scene of cancer patients requiring mechanical ventilation is frustrating. The needed life support measures drain much of health resources and add a significant burden on the patient's family. Many factors have been responsible for the high mortality rates among hematologic cancer patients admitted to intensive care unit. Among of these factors, the invasive treatments that are frequently employed in today's intensive care unit. These procedures give chance for development of severe infection and multiple organ failure which are common events in immune-compromised patients (e.g. neutropenia) and in those exposed to chemotherapy. The most common form of organ failure in those patients is acute respiratory failure which is a major predictor of mortality in that population. The prognosis of such failure may vary depending on its causes and severity, co morbidity, associated acute organ failure and characters of the underlying malignancy. After the recent advances in the field of intensive care and shedding light on the benefits of the noninvasive ventilation in immune-compromised patients, the overall survival rate of cancer patients admitted to intensive care unit are improving.
Study Type
OBSERVATIONAL
Enrollment
50
requiring mechanical ventilation at admission to ICU for one day or more during the study period
Mansoura Cancer Therapy Center
Al Mansurah, Dakahlia Governorate, Egypt
Survival
Continuing to live
Time frame: through study completion, an average of 30 days after admission to intensive care unit
Sequential Organ Failure Assessment score
Sequential Organ Failure Assessment (SOFA) Score
Time frame: up to 24 hours after admission to the intensive care unit
Simplified Acute Physiology Score II
Simplified Acute Physiology Score (SAPS II)
Time frame: up to 24 hours after admission to the intensive care unit
Mode of mechanical ventilation
synchronised intermittent, pressure-controlled, volume-controlled, pressure support, continuous positive airway pressure, volume guarantee, adjusted pressure release ventilation, or adaptive proportional assist ventilation
Time frame: up to 24 hours after admission to the intensive care unit
lowest Pa02/FiO2
PaO2 "arterial oxygen tension"/FiO2 "inspired fraction of oxygen" ratio
Time frame: up to 24 hours after admission to the intensive care unit
Reason for need of ventilatory support
Advanced malignancy, respiratory muscle weakness, respiratory failure, lung metastasis, coma, sepsis, multi-organs failure
Time frame: up to 24 hours after admission to the intensive care unit
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