Effect of Left Atrial Appendage Excision on Procedure Outcome in Patients With Persistent and Long-standing Persistent Atrial Fibrillation Undergoing Surgical Ablation

Meshalkin Research Institute of Pathology of Circulation180 enrolled

Overview

The aim of this study is to assess the effect of left atrial appendage excision on atrial fibrillation recurrence and incidence of stroke in patients with persistent and long-standing persistent atrial fibrillation undergoing surgical ablation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

180

Conditions

Atrial Fibrillation

Interventions

Surgical ablation of the left atrium (PVI+Box lesions)DEVICE

Surgical ablation of the left atrium (PVI+Box lesions) and left atrial appendage cuttingDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Key Inclusion Criteria: * Patients with persistent and long-standing persistent atrial fibrillation eligible for thoracoscopy surgical ablation * Signed inform consent Key Exclusion Criteria: * Paroxysmal atrial fibrillation * Contraindications for surgical ablation * Unwilling to participate

Locations (4)

Federal Center of Cardiovascular surgery

Krasnoyarsk, Russia

Federal State Institution Clinical Hospital of the Presidental Administration of the RF

Moscow, Russia

Scientific center of the cardiovascular surgery named by A.N. Bakulev

Moscow, Russia

State Research Institute of CIrculation Pathology

Novosibirsk, Russia

Outcomes

Primary Outcomes

Atrial fibrillation recurrences

Time frame: 18 months

Data from ClinicalTrials.gov

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