Impact of iv Dexamethasone on Reversal of Rocuronium-induced Neuromuscular Block by Sugammadex

Centre Hospitalier Universitaire Vaudois

Overview

Sugammadex is used as a reversal drug for rocuronium- or vecuronium-induced neuromuscular block during general anaesthesia. IV dexamethasone is injected as a prophylactic measure against postoperative nausea and vomiting. Recent animal data have shown that dexamethasone may impair the reversal effect of sugammadex. The objective of this randomised controlled trial is to confirm in the clinical practice these preliminary results.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Conditions

Neuromuscular Blockade

Interventions

Normal salineDRUG

IV dexamethasoneDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients scheduled to undergo microlaryngoscopy and ear-nose-throat endoscopic procedures Exclusion Criteria: * contraindication to dexamethasone administration * contraindication to sugammadex administration * contraindication to rocuronium administration

Locations (1)

Lausanne University Hospital

Lausanne, Canton of Vaud, Switzerland

Outcomes

Primary Outcomes

Mean recovery time for T4/T1 ratio > 90% after sugammadex administration

Time frame: surgical procedure

Secondary Outcomes

Mean recovery time for T4/T1 ratio > 80% after sugammadex administration

Time frame: surgical procedure

Mean recovery time for T4/T1 ratio > 70% after sugammadex administration

Time frame: surgical procedure

Data from ClinicalTrials.gov

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