Effect of BM-MSCs on Chronic AMR After Kidney Transplantation

Inclusion Criteria: * kidney transplantation * cAMR diagnosis is determined based on renal graft biopsy and DSA examination * Patient is willing and capable of giving written informed consent for study participation and able to participate in the study for 12 months Exclusion Criteria: * Combined or multi-organ transplantation * Women who are pregnant, intend to become pregnant in the next 1 years, breastfeeding, or have a positive pregnancy test on enrollment or prior to study medication administration * Donors or recipients are known hepatitis C antibody-positive or polymerase chain reaction (PCR) positive for hepatitis C * Donors or recipients are known hepatitis B surface antigen-positive or PCR positive for hepatitis B * Donors or recipients are known human immunodeficiency virus (HIV) infection * Patients with active infection * Recipients with a history of substance abuse (drugs or alcohol) within the past 6 months, or psychotic disorders that are not capable with adequate study follow- up * Patients with severe cardiovascular dysfunction * WBC\<3\*10\^9/L or RBC \<5g/dL * Highly allergic constitution or having severe history of allergies * Patients with active peptic ulcer disease, chronic diarrhea, or gastrointestinal problem affect absorption * Patients with a history of cancer within the last 5 years * Prisoner or patients compulsorily detained (involuntarily incarcerated) for treatment or either a psychiatric or physical (e.g. infectious disease) illness * Renal graft function deteriorates due to non-immunological complication, such as surgical issues or drug nephrotoxicity