To evaluate the safety of 3 regimens of short-term, low-dose systemic IMT as rejection prophylaxis prior to and/or following transplant of MA09-hRPE cells.
This study will be a Phase 2, double-masked, randomized, parallel group, sham surgery/placebo control, multi-center trial. Subjects will be randomized in a 3:1 ratio to either the treatment or control group respectively. Subjects randomized to the treatment group will receive transplantation with 200,000 MA09-hRPE (human embryonic stem cell derived retinal pigmented epithelial)cells in one eye. Subjects randomized to the control group will have a sham surgery without transplantation of MA09-hRPE cells. The study eye must meet all eligibility criteria. If both eyes meet all eligibility criteria, then the study eye will be the eye with the worst Best Corrected Visual Acuity (BCVA) score at screening. If both eyes have identical BCVA scores, then the study eye will be chosen by the Investigator and the subject. There will be 3 cohorts, each with a different regimen of low-dose IMT \[tacrolimus and mycophenolate mofetil (MMF)\]. Subjects will be randomized to treatment or control within cohorts, defined by severity of BCVA in the study eye at Screening. Enrollment in Cohort 1 and 2 will be concurrent. Enrollment into Cohort 3 will begin once Cohort 2 is fully enrolled.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
transplantation
Immunosuppressive Agents
placebo
Wills Eye Institute
Philadelphia, Pennsylvania, United States
Number of subjects with evidence of graft failure or rejection.
Time frame: 18 months
Change in area of geographic atrophy by Optical coherence tomography
Change from baseline to Week 78
Time frame: 18 months
Change in area of geographic atrophy by Autofluorescence
Change from baseline to Week 78
Time frame: 18 months
Change in average Best Corrected Visual Acuity (BCVA)
Change from baseline to Week 78
Time frame: 18 months
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Sham surgery