Effect of Amino Acids and Sugar Alcohols on Gastric Emptying and Release of Satiation Peptides in Humans

University Hospital, Basel, Switzerland20 enrolled

Overview

With this study the investigators investigate the effects of amino acids (tryptophan in two different concentrations, leucin) and sugar alcohols (xylitol, erythritol) on satiety mechanisms.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Endocrine System Diseases

Interventions

0.52 g L-TryptophanDIETARY_SUPPLEMENT

1.56 g L-TryptophanDIETARY_SUPPLEMENT

1.56 g L-LeucineDIETARY_SUPPLEMENT

50 g XylitolDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy normal weight subjects with a body-mass index of 19.0-24.9 * Healthy obese subjects with a body-mass index of \> 30 * Normal eating habits (no diets; no dietary changes; no special dietary habits, such as vegetarian/vegan) * Age 18-40 years * Stable body weight for at least three months Exclusion Criteria: * Smoking * Substance abuse * Regular intake of medications (except for oral contraceptives) * Medical or psychiatric illness * History of gastrointestinal disorders * Food allergies * Pregnancy, breast feeding

Locations (1)

University Hospital Basel, Phase 1 Research Unit

Basel, Switzerland