The purpose of this study is to assess the feasibility of conducting a trial to evaluate a self-help treatment for depression in people with end-stage renal disease.
Chronic Kidney Disease (CKD) is a long-term condition in which the function of the kidneys - to filter out waste products from the blood - slowly declines. When renal function becomes sufficiently low it is described as End Stage Renal Disease (ESRD) and renal replacement therapy (RRT) is likely to be needed to prolong life. The most common type of RRT is haemodialysis, in which the patient's blood is filtered through a machine. It is estimated that depression is experienced by 20-40% of people with ESRD. Depression not only affects the quality of life of individuals with ESRD but is also associated with higher rates of hospitalisation and poorer physical health outcomes. Acceptance and Commitment Therapy (ACT) has been found to be an effective treatment for depression and has been used successfully as a self-help treatment. However, no study has examined the effectiveness of an ACT self-help treatment for depression in ESRD. This study aims to assess the feasibility of conducting such a study and will look at suitability of recruitment, assessment methods and the acceptability of the self-help treatment, as well as helping to calculate the number of people needed for a definitive study. Haemodialysis patients receiving dialysis through an NHS renal service will be invited to participate. To participate they will be consenting, over 18 years of age and experiencing depressive symptoms at a clinical level. Those eligible will be randomly assigned into one of two conditions; a control condition receiving treatment as usual (TAU), and an intervention condition receiving TAU alongside an ACT self-help manual with weekly telephone support. The manual will be completed over six weeks. Both groups will be asked to complete questionnaires prior to intervention and 2 and 4 months post-intervention. Participants from each condition will be asked to participate in interviews to explore their experiences of taking part.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
9
Self-help book based upon principles of Acceptance and Commitment Therapy
Shipley Dialysis Unit, Ilkeston Community Hospital
Ilkeston, Derbyshire, United Kingdom
Mike Cassidy Dialysis Unit, Kings Mill Hospital
Mansfield, Nottinghamshire, United Kingdom
Main Dialysis Unit & Centenary Dialysis Unit (same site), City Hospital
Nottingham, Nottinghamshire, United Kingdom
Change in Patient Health Questionnaire (PHQ-9) at 2 and 4 months
Validated self-report questionnaire assessing symptoms of depression
Time frame: Baseline; 2 months; 4 months
Change in EQ-5D-5L at 2 and 4 months
Validated self-report questionnaire assessing health-related quality of life
Time frame: Baseline; 2 months; 4 months
Change in Acceptance and Action Questionnaire - 2 (AAQ-2) at 2 and 4 months
Validated self-report questionnaire assessing psychological flexibility
Time frame: Baseline; 2 months; 4 months
Change in Valued Living Questionnaire (VLQ) at 2 and 4 months
Validated self-report questionnaire assessing the extent to which individuals live consistently with their identified values
Time frame: Baseline; 2 months; 4 months
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