It is well documented that a few days stay in space induces a change in the vestibular-ocular reflex reflecting a reinterpretation of sensory inputs following the disappearance of gravity. If the change of eye reflexes actually the result of a reinterpretation of sensory input, the investigators should also expect to see an alteration of the vestibular-cardiovascular reflexes. The modification of these reflexes may modulate the carotid baroreflex and thus participate in the post-flight cardiovascular deconditioning. The first objective of this project is to study the carotid baroreflex under different supine (dorsal, ventral and lateral) inducing different otolith stimulation in normal-gravity.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
54
In each decubitus, trains of stimuli 8 (-80, -60, -40, -20, 0, 10, 20 and 40 Torr), with a duration of 500 milliseconds each, will be applied using a positive and negative pressure system placed around the neck of the subject.
Laboratoire de Physiologie, CHU de Caen
Caen, France
RECRUITINGArterial flow in Common Carotid Artery (EchoDoppler)
Measurements of Common Carotid Artery Blood Flow in Cm/s
Time frame: baseline
Arterial flow in Internal Carotid Artery (EchoDoppler)
Measurements of Internal Carotid Artery Blood Flow in Cm/s
Time frame: Baseline
Arterial flow in External Carotid Artery (EchoDoppler)
Measurements of External Carotid Artery Blood Flow in Cm/s
Time frame: Baseline
Arterial flow in Vertebral Artery (EchoDoppler)
Measurements of Vertebral Artery Blood Flow in Cm/s
Time frame: Baseline
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