The study is a Phase II, multi center, randomized, double-blind, placebo-controlled study in male and female subjects, aged ≥ 19 years with skin pruritus. All subjects will receive BID topical applications of PAC-14028 cream or vehicle for up to 4 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
296
Topical application
Topical application
Topical application
Seoul National University Hospital
Seoul, South Korea
Change in intensity of pruritus as measured by 10 cm VAS
Time frame: Week 4 from baseline
Treatment success rate (A decrease in VAS by 2 or more is judged as a success)
Time frame: Week 4 from baseline
Change in Overall Dry Skin (ODS) score
Time frame: Week 4 from baseline
Change in Transepidermal Water Loss (TEWL)
Time frame: Week 4 from baseline
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Topical application