Hyporesponsiveness of Natural Killer Cells and a Dysfunctional Inflammatory Response in Critically Ill Patients

Yonsei University48 enrolled

Overview

To investigate natural killer (NK) cell activities, circulating cytokine levels and peripheral blood mononuclear cell (PBMC) cytokine production status in critically ill patients.

Blood samples were collected \< 24 hours after admission from 24 intensive care unit (ICU) patients and 24 age-, sex-, and body mass index (BMI)-matched healthy controls. NK cell activities, cytokine concentrations and cytokine production by PBMCs and lipopolysaccharide (LPS)-stimulated PBMCs were measured.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Critical Illness

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ICU patients * For healthy controls: nondiabetic and nonobese subjects Exclusion Criteria: * For healthy controls: diabetes; history/presence of significant metabolic disease; pregnancy or breast-feeding; acute or chronic infection; liver disease; kidney disease; gastrointestinal disease; subjects taking any drugs or supplements

Outcomes

Primary Outcomes

NK cell activity

NK cell activity (%)

Time frame: Baseline

Secondary Outcomes

IL (Interleukin)-12

IL-12 (pg/mL)

Time frame: Baseline

hs-CRP (high-sensitivity C-reactive protein)

hs-CRP (mg/dL)

Time frame: Baseline

Data from ClinicalTrials.gov

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