Intrathecal morphine is commonly used as an analgesic adjunct for hip arthroplasty performed under spinal anaesthesia. Sleep apnea syndrome is a condition that affects up to 10% of the patients. Effect of intrathecal hydrophilic opioids on the frequency and duration of apneic episodes is unknown. The objective of this randomised controlled trial is to investigate the effect of intrathecal morphine and surgery on apneic episodes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
60
Isobaric bupivacaine 15 mg + normal saline 0.5 cc
Isobaric bupivacaine 15 mg + intrathecal morphine 100 mcg
Lausanne University Hospital
Lausanne, Switzerland
apnea hypopnea index while lying supine
Time frame: postoperative night 0
apnea hypopnea index while lying in another position than supine
Time frame: postoperative night 0
mean pulse oxymetry
Time frame: postoperative night 0
STOP-BANG questionnaire
Time frame: 24 h before surgery
Berlin questionnaire
Time frame: 24 h before surgery
Epworth questionnaire
Time frame: 24 h before surgery
pain scores (numeric rating scale, 0-10)
Time frame: postoperative day 0, 1, 2 and 3
oxycodone consumption (mg)
Time frame: postoperative day 0, 1, 2 and 3
postoperative nausea and vomiting (yes/no)
Time frame: postoperative day 0, 1, 2 and 3
Pruritus (yes/no)
Time frame: postoperative day 0, 1, 2 and 3
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.