Aging is a long term process, starting early in life, and progressively affecting various functions and organs. Cardiovascular diseases and cognitive impairment are two conditions related to advancing age and sharing common risk factors. The Mona Lisa- PREDOR study is a population-based prospective cohort study carried out to develop risk prediction algorithms aimed at identifying people who are the most likely to develop impaired psychometric and cognitive functioning and impaired cardiovascular risk, in the coming years.
The study is aimed at identifying predictors of impaired changes in psychometric and cognitive performances and level of cardiovascular risk, over a seven-year period, and to develop risk prediction algorithms. Main secondary objectives are to study response to psychometric and cognitive tests according to age, and to estimate the prevalence of the frailty syndrome according to age. The design is a prospective cohort study carried out among 1500 men and women from the general population, aged 42-89 years, and living in South-western France. Except for participants aged 80-89 years, all participants have been previously assessed in 2005-2007, as regard to their psychometric and cognitive performances and level of cardiovascular risk, as part of the Mona Lisa study. Data collection includes a detailed questionnaire on previous medical history, drug intake, education level, and life habits; a standardised clinical examination; psychometric tests (word list learning test, digit symbol substitution test, word fluency test and Stroop test), and a fasting blood sample. Level of cardiovascular risk and frailty syndrome were assessed.
Study Type
OBSERVATIONAL
Enrollment
520
Toulouse University Hospital
Toulouse, France
Test of memorizing and restitution of words
French version of the Rey auditory verbal learning test
Time frame: 7 years after the first assessment
Level of cardiovascular risk
Number of risk factors
Time frame: 7 years after the first assessment
Level of cardiovascular risk
10-years risk of cardiovascular event. A first assessment was performed in 2005-2007. A second one will be performed as part of the current study (2013-2016).
Time frame: 10 years after the first assessment
WAIS-DSST
Wechsler Adult Intelligence Survey - Digit Symbol Substitution Subtest
Time frame: 7 years after the first assessment
Stroop test
Time frame: 7 years after the first assessment
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